BDBM629463 US20230339981, Example 151::US20230339981, Example 153

SMILES Fc1ccc2cccc(-c3nc4CC[C@@H]5[C@@H]6CC[C@H](CN5c5nc(OC[C@@]78CCCN7[C@H](COc7ccnc(n7)C(F)(F)F)CC8)nc(c3F)c45)N6)c2c1C#C

InChI Key InChIKey=MIVADTZBVOXEBZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 629463   

TargetGTPase KRas [G12D](Human)
Gilead Sciences

US Patent
LigandPNGBDBM629463(US20230339981, Example 151 | US20230339981, Exampl...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for binding to GDP-loaded KRAS G12D in a 384-well assay format using a TR-FRET probe displacement assay in buffer consisting of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Gilead Sciences

US Patent
LigandPNGBDBM629463(US20230339981, Example 151 | US20230339981, Exampl...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for binding to GDP-loaded KRAS G12D in a 384-well assay format using a TR-FRET probe displacement assay in buffer consisting of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent