BDBM629422 US20230339981, Example 110::US20230339981, Example 147

SMILES Oc1cc(-c2nc3CC[C@@H]4[C@@H]5CC[C@H](CN4c4nc(OC[C@@]67CCCN6[C@H](COC(C6CC6)C(F)(F)F)CC7)nc(c2F)c34)N5)c2c(C#C)c(F)ccc2c1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 629422   

TargetGTPase KRas [G12D](Human)
Gilead Sciences

US Patent
LigandPNGBDBM629422(US20230339981, Example 110 | US20230339981, Exampl...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for binding to GDP-loaded KRAS G12D in a 384-well assay format using a TR-FRET probe displacement assay in buffer consisting of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Gilead Sciences

US Patent
LigandPNGBDBM629422(US20230339981, Example 110 | US20230339981, Exampl...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for binding to GDP-loaded KRAS G12D in a 384-well assay format using a TR-FRET probe displacement assay in buffer consisting of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent