BDBM629321 US20230339981, Example 1::US20240327434, Compound 8-p1

SMILES Oc1cc(-c2nc3OC[C@@H]4[C@@H]5CC[C@H](CN4c4nc(OC[C@@]67CCCN6C[C@H](F)C7)nc(c2F)c34)N5)c2c(F)c(F)ccc2c1

InChI Key InChIKey=HCZKVXIBRAENCR-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 629321   

TargetGTPase KRas [G12D](Human)
Gilead Sciences

US Patent
LigandPNGBDBM629321(US20230339981, Example 1 | US20240327434, Compound...)
Affinity DataIC50: 0.5nMAssay Description:Compounds were tested for binding to GDP-loaded KRAS G12D in a 384-well assay format using a TR-FRET probe displacement assay in buffer consisting of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
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TargetGTPase KRas [G12D](Human)
Gilead Sciences

US Patent
LigandPNGBDBM629321(US20230339981, Example 1 | US20240327434, Compound...)
Affinity DataKd:  0.100nMAssay Description:Biotinylated Avi-KRAS-WT or Avi-KRAS-G12D was diluted to 20 μg/mL with 1x HBS-P+(Cat. #BR1006-71) buffer containing 100 mM MgCl2, and then flowe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
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TargetGTPase KRas(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM629321(US20230339981, Example 1 | US20240327434, Compound...)
Affinity DataKd:  3.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent