BDBM629318 (1R,2R)-N-(5-(4-chloro-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[1,5-a]pyridin-2-yl)-2-fluorocyclopropane-1-carboxamide::US20230339978, Example 28

SMILES F[C@@H]1C[C@@H]1C(=O)Nc1cc2cc(ccn2n1)-c1cnc2[nH]ccc2c1Cl

InChI Key InChIKey=PELIWNRKLAFPFO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 629318   

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM629318((1R,2R)-N-(5-(4-chloro-1H-pyrrolo[2,3-b]pyridin-5-...)
Affinity DataIC50: 21.5nMAssay Description:GST-tagged recombinant human RIPK2(25 ng) is incubated with 5 µL of compounds (0.5% DMSO), 5 µL of MBP (0.5 µg/µl) and 5 µL of ATP (25 µM) in buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
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TargetTyrosine-protein kinase ABL1(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM629318((1R,2R)-N-(5-(4-chloro-1H-pyrrolo[2,3-b]pyridin-5-...)
Affinity DataIC50: 13.9nMAssay Description:c-Abl kinase activity was measured by Promega s ADP-Glo Assay. In this assay, His-tagged recombinant human ABL1 (0.25 ng/ l) is incubated with 5 L of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent