BDBM629311 (1R,2S)-2-fluoro-N-(5-(4-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[1,5-a]pyridin-2-yl)cyclopropane-1-carboxamide::US20230339978, Example 21

SMILES Cc1c(cnc2[nH]ccc12)-c1ccn2nc(NC(=O)[C@H]3C[C@@H]3F)cc2c1

InChI Key InChIKey=YIUOPZRKRRRSTC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 629311   

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM629311((1R,2S)-2-fluoro-N-(5-(4-methyl-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50: 8.25nMAssay Description:GST-tagged recombinant human RIPK2(25 ng) is incubated with 5 µL of compounds (0.5% DMSO), 5 µL of MBP (0.5 µg/µl) and 5 µL of ATP (25 µM) in buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM629311((1R,2S)-2-fluoro-N-(5-(4-methyl-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50: 3.30nMAssay Description:c-Abl kinase activity was measured by Promega s ADP-Glo Assay. In this assay, His-tagged recombinant human ABL1 (0.25 ng/ l) is incubated with 5 L of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent