BDBM629293 US20230339978, Example 3

SMILES Cc1nc2[nH]ccc2cc1-c1ccn2nc(NC(=O)[C@@H]3C[C@@H]3F)cc2c1

InChI Key InChIKey=DFMJWYNOKUEPJT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 629293   

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM629293(US20230339978, Example 3)
Affinity DataIC50: 25nMAssay Description:GST-tagged recombinant human RIPK2(25 ng) is incubated with 5 µL of compounds (0.5% DMSO), 5 µL of MBP (0.5 µg/µl) and 5 µL of ATP (25 µM) in buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
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TargetTyrosine-protein kinase ABL1(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM629293(US20230339978, Example 3)
Affinity DataIC50: 0.700nMAssay Description:c-Abl kinase activity was measured by Promega s ADP-Glo Assay. In this assay, His-tagged recombinant human ABL1 (0.25 ng/ l) is incubated with 5 L of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent