BDBM629043 4-[3-(5-Fluoro-2-pyridyl)-1-methyl-pyrazol-4-yl]-1H-pyrrolo[2,3-b]::US20230339900, Example 20::US20230339900, Example 54

SMILES Cn1cc(c(n1)-c1ccc(F)cn1)-c1ccnc2[nH]ccc12

InChI Key InChIKey=OAUWJBUJGOVSTR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 629043   

TargetCasein kinase I isoform delta(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM629043(US20230339900, Example 20 | US20230339900, Example...)
Affinity DataIC50: 70nMAssay Description:In this assay, CSNK1D phosphorylates a substrate peptide PLSRTL-pS-VASLPGL in the presence of ATP. This substrate peptide has been modeled after the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent

TargetCasein kinase I isoform delta(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM629043(US20230339900, Example 20 | US20230339900, Example...)
Affinity DataIC50: 54nMAssay Description:In this assay, CSNK1D phosphorylates a substrate peptide PLSRTL-pS-VASLPGL in the presence of ATP. This substrate peptide has been modeled after the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent

TargetCasein kinase I isoform delta(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM629043(US20230339900, Example 20 | US20230339900, Example...)
Affinity DataIC50: 71nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM629043(US20230339900, Example 20 | US20230339900, Example...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human CK1 delta expressed in Escherichia coli BL21 cells using PLSRTL-pS-VA-pS-LPGL as substrate meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM629043(US20230339900, Example 20 | US20230339900, Example...)
Affinity DataIC50: 930nMAssay Description:Inhibition of p38 alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 11(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM629043(US20230339900, Example 20 | US20230339900, Example...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of p38 beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed