BDBM628659 (3R)-3-(4-Chlorophenyl)-2-[(5-chloropyridin-2-yl)methyl]-4-fluoro-3-({1- [hydroxy(2H2)methyl]cyclopropyl}(2H2)methoxy)-6-(2-hydroxy-1-methoxypropan-2-yl)-2,3-dihydro- 1H-isoindol-1-one::US20230338337, Compound 24::US20230338337, Compound 25

SMILES COCC(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cn3)[C@@](c2c(F)c1)(c1ccc(Cl)cc1)C1(O)CC1C

InChI Key InChIKey=PDDZMZJKQJSSKF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 628659   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM628659(US20230338337, Compound 24 | US20230338337, Compou...)
Affinity DataIC50: 7.70nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM628659(US20230338337, Compound 24 | US20230338337, Compou...)
Affinity DataIC50: 1.80nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent