BDBM628437 US11795173, Example 30::US11795173, Example 6

SMILES CNC(=O)c1ccc(N2CCN(Cc3ccc4c5occc5c(=O)[nH]c4c3F)CC2)c(F)n1

InChI Key InChIKey=IXGZNTGACBFAFA-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 628437   

TargetPoly [ADP-ribose] polymerase 1(Human)
Xinthera

US Patent
LigandPNGBDBM628437(US11795173, Example 6 | US11795173, Example 30)
Affinity DataIC50: 21nMAssay Description:Compounds were dissolved in DMSO an Echo550 liquid handler was utilized to make serial dilations in the desired concentration range in Optiplate-384F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Xinthera

US Patent
LigandPNGBDBM628437(US11795173, Example 6 | US11795173, Example 30)
Affinity DataIC50: 1.00E+5nMAssay Description:Compounds were dissolved in DMSO an Echo550 liquid handler was utilized to make serial dilations in the desired concentration range in Optiplate-384F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Xinthera

US Patent
LigandPNGBDBM628437(US11795173, Example 6 | US11795173, Example 30)
Affinity DataIC50: 56nMAssay Description:Compounds were dissolved in DMSO an Echo550 liquid handler was utilized to make serial dilations in the desired concentration range in Optiplate-384F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Xinthera

US Patent
LigandPNGBDBM628437(US11795173, Example 6 | US11795173, Example 30)
Affinity DataIC50: 1.00E+5nMAssay Description:Compounds were dissolved in DMSO an Echo550 liquid handler was utilized to make serial dilations in the desired concentration range in Optiplate-384F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Xinthera

US Patent
LigandPNGBDBM628437(US11795173, Example 6 | US11795173, Example 30)
Affinity DataIC50: 21nMAssay Description:PARP1 and PARP2 protein were expressed, purified, and diluted in assay buffer containing 50 mM Tris pH 8.0, 0.001% Triton X-100, 10 mM MgCI2, 150 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Xinthera

US Patent
LigandPNGBDBM628437(US11795173, Example 6 | US11795173, Example 30)
Affinity DataIC50: 1.00E+5nMAssay Description:PARP1 and PARP2 protein were expressed, purified, and diluted in assay buffer containing 50 mM Tris pH 8.0, 0.001% Triton X-100, 10 mM MgCI2, 150 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Xinthera

US Patent
LigandPNGBDBM628437(US11795173, Example 6 | US11795173, Example 30)
Affinity DataIC50: 56nMAssay Description:PARP1 and PARP2 protein were expressed, purified, and diluted in assay buffer containing 50 mM Tris pH 8.0, 0.001% Triton X-100, 10 mM MgCI2, 150 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Xinthera

US Patent
LigandPNGBDBM628437(US11795173, Example 6 | US11795173, Example 30)
Affinity DataIC50: 1.00E+5nMAssay Description:PARP1 and PARP2 protein were expressed, purified, and diluted in assay buffer containing 50 mM Tris pH 8.0, 0.001% Triton X-100, 10 mM MgCI2, 150 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
Go to US Patent