BDBM628434 (Example 4 in CN115232129A)::US11795173, Example 4

SMILES Cc1cc2n(n1)c1ccc(CN3CCN(CC3)c3ccc(nc3F)C(=O)NC3CC3)c(F)c1[nH]c2=O

InChI Key InChIKey=JFHWEAQATAEPIL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 628434   

TargetPoly [ADP-ribose] polymerase 1(Human)
Xinthera

US Patent
LigandPNGBDBM628434(US11795173, Example 4 | (Example 4 in CN115232129A...)
Affinity DataIC50: 16nMAssay Description:Compounds were dissolved in DMSO an Echo550 liquid handler was utilized to make serial dilations in the desired concentration range in Optiplate-384F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Xinthera

US Patent
LigandPNGBDBM628434(US11795173, Example 4 | (Example 4 in CN115232129A...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compounds were dissolved in DMSO an Echo550 liquid handler was utilized to make serial dilations in the desired concentration range in Optiplate-384F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Xinthera

US Patent
LigandPNGBDBM628434(US11795173, Example 4 | (Example 4 in CN115232129A...)
Affinity DataIC50: 16nMAssay Description:PARP1 and PARP2 protein were expressed, purified, and diluted in assay buffer containing 50 mM Tris pH 8.0, 0.001% Triton X-100, 10 mM MgCI2, 150 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Xinthera

US Patent
LigandPNGBDBM628434(US11795173, Example 4 | (Example 4 in CN115232129A...)
Affinity DataIC50: 1.00E+5nMAssay Description:PARP1 and PARP2 protein were expressed, purified, and diluted in assay buffer containing 50 mM Tris pH 8.0, 0.001% Triton X-100, 10 mM MgCI2, 150 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
Go to US Patent