BDBM62810 2-amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile::2-amino-6-methyl-4-(3-pyridyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile::2-amino-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydroquinoline-3-carbonitrile::2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydroquinoline-3-carbonitrile::MLS000114823::SMR000092114::cid_3835861

SMILES CC1CCc2nc(N)c(C#N)c(-c3cccnc3)c2C1

InChI Key InChIKey=QSYBDNXNOJIKML-UHFFFAOYSA-N

Data  9 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 62810   

TargetHeat shock factor protein 1(Mouse)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM62810(2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydr...)
Affinity DataEC50:  1.83E+3nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2011
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 19(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM62810(2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CDK19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 8(Mouse)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM62810(2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydr...)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of CDK8/Cyclin-C in R848-stimulated mouse BMDC assessed as upregulation of IL-10 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM62810(2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydr...)
Affinity DataIC50: 500nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM62810(2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human GST/His-tagged CDK11 (1 to 502 residues)/cyclinC (1 to 283 residues) catalytic domain expressed in insect cells by La...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCyclin-C(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM62810(2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydr...)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant full-length human His-tagged CDK8/cyclinC expressed in baculovirus expression system by Lantha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCyclin-C(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM62810(2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydr...)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant full-length human His-tagged CDK8/cyclinC expressed in baculovirus expression system by Lantha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM62810(2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human GST/His-tagged CDK11 (1 to 502 residues)/cyclinC (1 to 283 residues) catalytic domain expressed in insect cells by La...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM62810(2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydr...)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 19(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM62810(2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant CDK19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-C(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM62810(2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydr...)
Affinity DataIC50: 211nMAssay Description:Inhibition of recombinant full length His tagged human CDK8/Cyclin C expressed in Baculovirus incubated for 60 mins in presence of ATP by ADP-Glo kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed