BDBM627350 (S,E)-1-(2-Methoxy-4-(2-(2-methyl-[1,1'-biphenyl]-3-yl)vinyl)-5-trifluoromethylbenzyl)piperidine-2-carboxylic acid::US20230331675, Compound 6::US20230331675, Compound 60::US20230331675, Compound 61::US20230331675, Compound 72

SMILES COc1cc(\C=C\c2cccc(c2C)-c2ccccc2)c(cc1CN1CCCC[C@H]1C(O)=O)C(F)(F)F

InChI Key InChIKey=OMRMLTBTDTUNFN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 627350   

TargetProgrammed cell death 1 ligand/protein 1(Human)
Guangzhou Maxinovel Pharmaceuticals

US Patent
LigandPNGBDBM627350(US20230331675, Compound 6 | (S,E)-1-(2-Methoxy-4-(...)
Affinity DataIC50: 1.60nMAssay Description:Homogeneous time-resolved fluorescence (HTRF) binding assay was used to determine the binding ability of the compound of the present disclosure to PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2023
Entry Details
Go to US Patent

TargetProgrammed cell death 1 ligand/protein 1(Human)
Guangzhou Maxinovel Pharmaceuticals

US Patent
LigandPNGBDBM627350(US20230331675, Compound 6 | (S,E)-1-(2-Methoxy-4-(...)
Affinity DataIC50: 0.590nMAssay Description:Homogeneous time-resolved fluorescence (HTRF) binding assay was used to determine the binding ability of the compound of the present disclosure to PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2023
Entry Details
Go to US Patent

TargetProgrammed cell death 1 ligand/protein 1(Human)
Guangzhou Maxinovel Pharmaceuticals

US Patent
LigandPNGBDBM627350(US20230331675, Compound 6 | (S,E)-1-(2-Methoxy-4-(...)
Affinity DataIC50: 0.730nMAssay Description:Homogeneous time-resolved fluorescence (HTRF) binding assay was used to determine the binding ability of the compound of the present disclosure to PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2023
Entry Details
Go to US Patent

TargetProgrammed cell death 1 ligand/protein 1(Human)
Guangzhou Maxinovel Pharmaceuticals

US Patent
LigandPNGBDBM627350(US20230331675, Compound 6 | (S,E)-1-(2-Methoxy-4-(...)
Affinity DataIC50: 2nMAssay Description:Homogeneous time-resolved fluorescence (HTRF) binding assay was used to determine the binding ability of the compound of the present disclosure to PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2023
Entry Details
Go to US Patent