BDBM626965 (racemic)-(2s,4S)-2-((3R,4R)-4-(4-(tert-Butyl)phenyl)-3- methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;::US11787798, Example 141::US11787798, Example 142::US11787798, Example 144

SMILES C[C@H]1CN(CC[C@H]1c1ccc(cc1)C(C)(C)C)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2

InChI Key InChIKey=RKFOGZFQBVTJPV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 626965   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM626965(US11787798, Example 141 | US11787798, Example 144 ...)
Affinity DataIC50: 0.200nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM626965(US11787798, Example 141 | US11787798, Example 144 ...)
Affinity DataIC50: 0.400nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM626965(US11787798, Example 141 | US11787798, Example 144 ...)
Affinity DataIC50: 2.5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent