BDBM626870 (2s,4s)-2-(4-(4-Phenoxyphenyl)piperidine-1-carbonyl)-7-oxa-5- azaspiro[3.4]octan-6-one;::US11787798, Example 48::US11787798, Example 51

SMILES O=C([C@H]1C[C@@]2(C1)COC(=O)N2)N1CCC(CC1)c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=TULYCLZIDSHGHJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 626870   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM626870(US11787798, Example 48 | US11787798, Example 51 | ...)
Affinity DataIC50: 0.700nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM626870(US11787798, Example 48 | US11787798, Example 51 | ...)
Affinity DataIC50: 4.20nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent