BDBM626341 2-[[[4-cyano-7-(2,6-difluoro-4- isopropyl-phenyl)-2,3- dihydrobenzofuran-5- yl]amino]methyl]prop-2-enoic acid::US11787775, Compound 28

SMILES CC(C)c1cc(F)c(c(F)c1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2CCOc12

InChI Key InChIKey=QQSSJQGNBKZTSJ-UHFFFAOYSA-N

Data  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 626341   

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM626341(2-[[[4-cyano-7-(2,6-difluoro-4- isopropyl-phenyl)...)
Affinity DataIC50: 690nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
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TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM626341(2-[[[4-cyano-7-(2,6-difluoro-4- isopropyl-phenyl)...)
Affinity DataIC50: 350nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM626341(2-[[[4-cyano-7-(2,6-difluoro-4- isopropyl-phenyl)...)
Affinity DataIC50: 1.60E+4nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM626341(2-[[[4-cyano-7-(2,6-difluoro-4- isopropyl-phenyl)...)
Affinity DataIC50: 320nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626341(2-[[[4-cyano-7-(2,6-difluoro-4- isopropyl-phenyl)...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626341(2-[[[4-cyano-7-(2,6-difluoro-4- isopropyl-phenyl)...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626341(2-[[[4-cyano-7-(2,6-difluoro-4- isopropyl-phenyl)...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626341(2-[[[4-cyano-7-(2,6-difluoro-4- isopropyl-phenyl)...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent