BDBM625597 US20230322822, Compound 12
SMILES CCc1cc(Nc2ncc(Br)c(Nc3ccc(C)cc3P(C)(C)=O)n2)c(OC)cc1N1CCC(CC1)N1CCN(C)CC1
InChI Key InChIKey=MTJABDOZWOEWJD-UHFFFAOYSA-N
Data 15 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 625597
TargetEpidermal growth factor receptor [1-18,20-1210](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 33.7nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 9.80nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 6.90nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 20.5nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 16.9nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 7.5nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 21.3nMAssay Description:To assess the effect of compounds on the activity of EML4-ALK kinases, kinase activity was tested by measuring ATP consumption in an enzymatic reacti...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 8.10nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 29.3nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 24.6nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [L858R,C797S](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 113nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 37.1nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 13.5nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Affinity DataIC50: 785nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair