BDBM625592 US20230322822, Compound 2

SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1

InChI Key InChIKey=CFKDUEIETGGIRT-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 625592   

TargetEpidermal growth factor receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetEpidermal growth factor receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 0.270nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetEpidermal growth factor receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 0.480nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetALK tyrosine kinase receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 0.770nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetALK tyrosine kinase receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 0.890nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetALK tyrosine kinase receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 0.910nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetALK tyrosine kinase receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetALK tyrosine kinase receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetEpidermal growth factor receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetEpidermal growth factor receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetALK tyrosine kinase receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 3.90nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 4.20nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 6.5nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 13.8nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 16.5nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 17.3nMAssay Description:To assess the effect of compounds on the activity of EML4-ALK kinases, kinase activity was tested by measuring ATP consumption in an enzymatic reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 21.3nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 22.5nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 23.5nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 24.8nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 32.6nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 48.1nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 64nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 64.1nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 169nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1.26E+3nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent