BDBM625349 US20230322769, Compound 58::US20230322769, Compound 67

SMILES COc1ccc(CN2CCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn3CCCc23)cn1

InChI Key InChIKey=RQJGLDQSQBZHDJ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 625349   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625349(US20230322769, Compound 67 | US20230322769, Compou...)
Affinity DataIC50: 4.98nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625349(US20230322769, Compound 67 | US20230322769, Compou...)
Affinity DataIC50: 19.4nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [M918T](Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625349(US20230322769, Compound 67 | US20230322769, Compou...)
Affinity DataIC50: 9.52nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetCoiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625349(US20230322769, Compound 67 | US20230322769, Compou...)
Affinity DataIC50: 8.07nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625349(US20230322769, Compound 67 | US20230322769, Compou...)
Affinity DataIC50: 134nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625349(US20230322769, Compound 67 | US20230322769, Compou...)
Affinity DataIC50: 0.790nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625349(US20230322769, Compound 67 | US20230322769, Compou...)
Affinity DataIC50: 1.09nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [M918T](Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625349(US20230322769, Compound 67 | US20230322769, Compou...)
Affinity DataIC50: 0.75nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetCoiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625349(US20230322769, Compound 67 | US20230322769, Compou...)
Affinity DataIC50: 0.340nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625349(US20230322769, Compound 67 | US20230322769, Compou...)
Affinity DataIC50: 24.6nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent