BDBM625348 US20230322769, Compound 57::US20230322769, Compound 66

SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1

InChI Key InChIKey=VWDJZFSVNMUGSS-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 625348   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625348(US20230322769, Compound 66 | US20230322769, Compou...)
Affinity DataIC50: 2.24nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625348(US20230322769, Compound 66 | US20230322769, Compou...)
Affinity DataIC50: 4.33nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [M918T](Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625348(US20230322769, Compound 66 | US20230322769, Compou...)
Affinity DataIC50: 4.06nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetCoiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625348(US20230322769, Compound 66 | US20230322769, Compou...)
Affinity DataIC50: 4.44nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625348(US20230322769, Compound 66 | US20230322769, Compou...)
Affinity DataIC50: 7.40nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625348(US20230322769, Compound 66 | US20230322769, Compou...)
Affinity DataIC50: 1.66nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625348(US20230322769, Compound 66 | US20230322769, Compou...)
Affinity DataIC50: 7.69nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [M918T](Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625348(US20230322769, Compound 66 | US20230322769, Compou...)
Affinity DataIC50: 2.05nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetCoiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625348(US20230322769, Compound 66 | US20230322769, Compou...)
Affinity DataIC50: 1.13nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625348(US20230322769, Compound 66 | US20230322769, Compou...)
Affinity DataIC50: 124nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent