BDBM622549 (7S)-2-(((trans-1-(3-(4-fluorophenyl)cyclobutyl)-1H-pyrazol-4-yl)methyl)amino)-4,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 112

SMILES C[C@@H]1N(C)c2nc(NCc3cnn(c3)[C@H]3C[C@@H](C3)c3ccc(F)cc3)nc(C)c2NC1=O

InChI Key InChIKey=XSIKBIVCYSIVSI-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 622549   

TargetSerine/threonine-protein kinase PLK1(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM622549(US20230312587, Compound 112 | (7S)-2-(((trans-1-(...)
Affinity DataKi: >4.00E+3nMAssay Description:Compounds were screened for their ability to inhibit Plk1 using a radioactive-phosphate incorporation assay. Assays were carried out in a mixture of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent