BDBM622545 (7S)-2-(((1-(3,5-difluoro-4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)amino)-5,8-diethyl-7-(2-hydroxyethyl)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 48

SMILES CCN1[C@@H](CCO)C(=O)N(CC)c2cnc(NCc3cnn(Cc4cc(F)c(OC)c(F)c4)c3)nc12

InChI Key InChIKey=CCAPEBQULINXFU-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 622545   

TargetSerine/threonine-protein kinase PLK1(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM622545(US20230312587, Compound 48 | (7S)-2-(((1-(3,5-difl...)
Affinity DataKi: >4.00E+3nMAssay Description:Compounds were screened for their ability to inhibit Plk1 using a radioactive-phosphate incorporation assay. Assays were carried out in a mixture of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
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