BDBM622284 4-amino-N-(1-((3-chloro-4-fluorophenyl)amino)-6-methylisoquinolin-5-yl)imidazo[2,1-f][1,2,4]triazine-7-carboxamide ::US20230312556, Compound 58

SMILES Cc1ccc2c(Nc3ccc(F)c(Cl)c3)nccc2c1NC(=O)c1cnc2c(N)ncnn12

InChI Key InChIKey=NXYYXOMFJOFJRB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 622284   

TargetSerine/threonine-protein kinase B-raf(Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622284(4-amino-N-(1-((3-chloro-4-fluorophenyl)amino)-6-me...)
Affinity DataIC50: 10.8nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
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TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622284(4-amino-N-(1-((3-chloro-4-fluorophenyl)amino)-6-me...)
Affinity DataIC50: 4.47nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
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TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622284(4-amino-N-(1-((3-chloro-4-fluorophenyl)amino)-6-me...)
Affinity DataIC50: 2.68nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent