BDBM622272 (R)-N-(2-(4-cyanothiazolidin-3-yl)-2-oxoethyl)-quinoline-4-carboxamide::US20230312550, Reference Compound C::US20230406840, Example C

SMILES O=C(CNC(=O)c1ccnc2ccccc12)N1CSC[C@H]1C#N

InChI Key InChIKey=XLOXHPAFGDSZIU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 622272   

TargetPresequence protease, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM622272(US20230312550, Reference Compound C | (R)-N-(2-(4-...)
Affinity DataIC50: 7.10nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM622272(US20230312550, Reference Compound C | (R)-N-(2-(4-...)
Affinity DataIC50: 7.10nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
Go to US Patent