BDBM6219 BMCL182776 Compound 1::Chlorobenzodioxole deriv. 28::N-(5-chloro-2H-1,3-benzodioxol-4-yl)-6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-amine

SMILES COc1cc2c(cc1OCCCN3CCCCC3)ncnc2Nc4c(ccc5c4OCO5)Cl

InChI Key InChIKey=QHIMVPIOWKYPSO-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 6219   

LigandPNGBDBM6219(BMCL182776 Compound 1 | N-(5-chloro-2H-1,3-benzodi...)
Affinity DataIC50: 2.17E+4nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2005
Entry Details Article
PubMed
LigandPNGBDBM6219(BMCL182776 Compound 1 | N-(5-chloro-2H-1,3-benzodi...)
Affinity DataIC50: 4nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-RRTK activity. The compounds were incubated with enzyme 20 min at room ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2005
Entry Details Article
PubMed
LigandPNGBDBM6219(BMCL182776 Compound 1 | N-(5-chloro-2H-1,3-benzodi...)
Affinity DataIC50: 1.00E+5nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandPNGBDBM6219(BMCL182776 Compound 1 | N-(5-chloro-2H-1,3-benzodi...)
Affinity DataIC50: 1.00E+5nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2005
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Astrazeneca

LigandPNGBDBM6219(BMCL182776 Compound 1 | N-(5-chloro-2H-1,3-benzodi...)
Affinity DataIC50: 350nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM6219(BMCL182776 Compound 1 | N-(5-chloro-2H-1,3-benzodi...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant pp60c-src expressed in baculovirus infected Sf9 insect cells using poly(Glu,Tyr) 4:1 as substrate after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM6219(BMCL182776 Compound 1 | N-(5-chloro-2H-1,3-benzodi...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human c-SRC expressed in mouse NIH/3T3 cells assessed as reduction in BrdU incorporation after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed