BDBM621871 (S)-N-((R or S)-(5- chloro-6- cyclopropylpyridin-2- yl)(4- (trifluoromethoxy)phenyl) methyl)-2- oxoimidazolidine-4- carboxamide::US20230312528, Example 40A::US20230312528, Example 40B

SMILES FC(F)(F)Oc1ccc(cc1)[C@@H](NC(=O)[C@@H]1CNC(=O)N1)c1ccc(Cl)c(n1)C1CC1

InChI Key InChIKey=FTFDCHIJNZAHRH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 621871   

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621871((S)-N-((R or S)-(5- chloro-6- cyclopropylpyridin-2...)
Affinity DataIC50: 21nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
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TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621871((S)-N-((R or S)-(5- chloro-6- cyclopropylpyridin-2...)
Affinity DataIC50: 3.5nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent