BDBM621836 US20230312528, Example 23B

SMILES Fc1ccc([C@@H](C[C@H]2CC[C@@H](CC2)C(F)(F)F)NC(=O)[C@@H]2CNC(=O)N2)c(F)c1Cl

InChI Key InChIKey=OYROJSBSFMSBQI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 621836   

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621836(US20230312528, Example 23B)
Affinity DataIC50: 4.90nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent