BDBM621182 US20230303564, Compound 24

SMILES C[C@@H]1CN(CC[C@@H]1Nc1ncc2cc(nc(N[C@@H]3CCCC3(F)F)c2n1)C(F)F)C(=O)OC(C)(C)C

InChI Key InChIKey=IUCBKFYHAZXUSO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 621182   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621182(US20230303564, Compound 24)
Affinity DataIC50: 3.60nMAssay Description:Enzymes, substrates, ATP, and inhibitors were diluted by kinase buffer in the kit. The compounds to be tested were diluted 5-fold with a multi-channe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621182(US20230303564, Compound 24)
Affinity DataIC50: 19.4nMAssay Description:Preparation of Kinase Buffer: The composition of the buffer: 50 mM of hydroxyethylpiperazine ethanesulfonic acid solution at pH 7.5, 1 mM of ethylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621182(US20230303564, Compound 24)
Affinity DataIC50: 10.8nMAssay Description:Preparation of Kinase Buffer: The composition of the buffer: 50 mM of hydroxyethylpiperazine ethanesulfonic acid solution at pH 7.5, 1 mM of ethylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent