BDBM621180 US20230303564, Compound 22

SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2cc(nc(N[C@@H]3CCCC3(F)F)c2n1)C(F)F

InChI Key InChIKey=DJXMWMFZMCZDNH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 621180   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621180(US20230303564, Compound 22)
Affinity DataIC50: 8.86nMAssay Description:Enzymes, substrates, ATP, and inhibitors were diluted by kinase buffer in the kit. The compounds to be tested were diluted 5-fold with a multi-channe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621180(US20230303564, Compound 22)
Affinity DataIC50: 3.52nMAssay Description:Enzymes, substrates, ATP, and inhibitors were diluted by kinase buffer in the kit. The compounds to be tested were diluted 5-fold with a multi-channe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621180(US20230303564, Compound 22)
Affinity DataIC50: 0.5nMAssay Description:Preparation of Kinase Buffer: The composition of the buffer: 50 mM of hydroxyethylpiperazine ethanesulfonic acid solution at pH 7.5, 1 mM of ethylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621180(US20230303564, Compound 22)
Affinity DataIC50: 1.36nMAssay Description:Preparation of Kinase Buffer: The composition of the buffer: 50 mM of hydroxyethylpiperazine ethanesulfonic acid solution at pH 7.5, 1 mM of ethylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621180(US20230303564, Compound 22)
Affinity DataIC50: 80.5nMAssay Description:Enzymes, substrates (MBP), ATP, and inhibitors were diluted by kinase buffer in the kit. The compounds to be tested were diluted 5-fold with a multi-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621180(US20230303564, Compound 22)
Affinity DataIC50: 36.9nMAssay Description:Enzymes, substrates, ATP, and inhibitors were diluted by kinase buffer in the kit. The compounds to be tested were diluted 5-fold with a multi-channe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent