BDBM621177 US20230303564, Compound 19

SMILES Cc1cn(C)nc1Nc1nc(cc2cnc(NC3CCN(CC3)S(C)(=O)=O)nc12)C(F)F

InChI Key InChIKey=IFYFSFOYHMKQFI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 621177   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621177(US20230303564, Compound 19)
Affinity DataIC50: 4.73nMAssay Description:Enzymes, substrates, ATP, and inhibitors were diluted by kinase buffer in the kit. The compounds to be tested were diluted 5-fold with a multi-channe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621177(US20230303564, Compound 19)
Affinity DataIC50: 4.26nMAssay Description:Preparation of Kinase Buffer: The composition of the buffer: 50 mM of hydroxyethylpiperazine ethanesulfonic acid solution at pH 7.5, 1 mM of ethylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621177(US20230303564, Compound 19)
Affinity DataIC50: 1.15nMAssay Description:Preparation of Kinase Buffer: The composition of the buffer: 50 mM of hydroxyethylpiperazine ethanesulfonic acid solution at pH 7.5, 1 mM of ethylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621177(US20230303564, Compound 19)
Affinity DataIC50: 178nMAssay Description:Enzymes, substrates, ATP, and inhibitors were diluted by kinase buffer in the kit. The compounds to be tested were diluted 5-fold with a multi-channe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent