BDBM621175 US20230303564, Compound 14

SMILES C[C@@]1(O)CCC[C@H]1Nc1nc(cc2cnc(NC3CCN(CC3)S(C)(=O)=O)nc12)C(F)F

InChI Key InChIKey=RRVFHLPDTJWOJK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 621175   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621175(US20230303564, Compound 14)
Affinity DataIC50: 1.25nMAssay Description:Enzymes, substrates, ATP, and inhibitors were diluted by kinase buffer in the kit. The compounds to be tested were diluted 5-fold with a multi-channe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621175(US20230303564, Compound 14)
Affinity DataIC50: 4.15nMAssay Description:Enzymes, substrates, ATP, and inhibitors were diluted by kinase buffer in the kit. The compounds to be tested were diluted 5-fold with a multi-channe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621175(US20230303564, Compound 14)
Affinity DataIC50: 2.59nMAssay Description:Preparation of Kinase Buffer: The composition of the buffer: 50 mM of hydroxyethylpiperazine ethanesulfonic acid solution at pH 7.5, 1 mM of ethylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
Medshine Discovery

US Patent
LigandPNGBDBM621175(US20230303564, Compound 14)
Affinity DataIC50: 1.69nMAssay Description:Preparation of Kinase Buffer: The composition of the buffer: 50 mM of hydroxyethylpiperazine ethanesulfonic acid solution at pH 7.5, 1 mM of ethylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent