BDBM621118 US20230303563, Compound 154

SMILES COc1ccn2c(cnc2c1)-c1cccc(N[C@H]2CNC[C@@H]2F)n1

InChI Key InChIKey=MCOWNEICYXDEPL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 621118   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621118BDBM621118(US20230303563, Compound 154)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621118BDBM621118(US20230303563, Compound 154)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621118BDBM621118(US20230303563, Compound 154)
Affinity DataIC50: 0.700nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621118BDBM621118(US20230303563, Compound 154)
Affinity DataIC50: 0.800nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621118BDBM621118(US20230303563, Compound 154)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621118BDBM621118(US20230303563, Compound 154)
Affinity DataIC50: 28nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent