BDBM621054 US12054482, Example 1::US20230303557, Example formula (I)

SMILES CCCC[C@](C)(Cc1ncn[nH]1)Nc1nc(N)nc2cnccc12

InChI Key InChIKey=MFXIZGDOEUUJFM-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 621054   

TargetToll-like receptor 8(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM621054(US20230303557, Example formula (I) | US12054482, E...)
Affinity DataEC50:  3nMAssay Description:1. The compound was added to a cell plate in a 3-fold gradient, with 10 concentrations (5000 nM, 1667 nM, 556 nM, 185 nM, 62 nM, 21 nM, 6.9 nM, 2.3 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM621054(US20230303557, Example formula (I) | US12054482, E...)
Affinity DataEC50:  3.33E+4nMAssay Description:1. The compound was added to a cell plate in a 3-fold gradient, with 10 concentrations (5000 nM, 1667 nM, 556 nM, 185 nM, 62 nM, 21 nM, 6.9 nM, 2.3 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM621054(US20230303557, Example formula (I) | US12054482, E...)
Affinity DataEC50:  3nMAssay Description:The experimental procedures are as follows:1. Compound was added to a cell plate in a 3-fold gradient, with the final concentrations being 5000 nM, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM621054(US20230303557, Example formula (I) | US12054482, E...)
Affinity DataEC50:  3.33E+4nMAssay Description:The experimental procedures are as follows:1. Compound was added to a cell plate in a 3-fold gradient, with the final concentrations being 5000 nM, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent