BDBM620971 (3S,4S) or (3R, 4R)-4-((R) or (S)- 4-(6-chloro-2-((5-chloro-1- cyclopropyl-1H-pyrazol-4- yl)amino)quinazolin-7-yl)-3- methylpiperazin-1- yl)tetrahydrofuran-3-ol::US20230303540, Example Ex-12.8::US20230303540, Example Ex-12.9

SMILES CC1CN(CCN1c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl)C1COCC1O

InChI Key InChIKey=CPNFCXHPDFAFDW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 620971   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620971((3S,4S) or (3R, 4R)-4-((R) or (S)- 4-(6-chloro-2-(...)
Affinity DataIC50: 0.0880nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620971((3S,4S) or (3R, 4R)-4-((R) or (S)- 4-(6-chloro-2-(...)
Affinity DataIC50: 8.64nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent