BDBM620922 (3R,4R)-4-(4-(6-chloro-2-((1- cyclopropyl-5-(difluoromethyl)- 1H-pyrazol-4- yl)amino)quinazolin-7- yl)piperazin-1-yl)-4- methyltetrahydrofuran-3-ol::US20230303540, Example Ex-6.56

SMILES C[C@]1(COC[C@@H]1O)N1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3C(F)F)ncc2cc1Cl

InChI Key InChIKey=AFHLMMMFIVGLHS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 620922   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620922((3R,4R)-4-(4-(6-chloro-2-((1- cyclopropyl-5-(diflu...)
Affinity DataIC50: 0.0800nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent