BDBM620875 1-(6-chloro-2-{[1-(2,2-(R) or (S) difluorocyclopropyl)-5-methyl- 1H-pyrazol-4- yl]amino}quinazolin-7-yl)-4- methylpiperidin-4-ol::US20230303540, Example Ex-6.10::US20230303540, Example Ex-6.9

SMILES Cc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(C)(O)CC2)cnn1C1CC1(F)F

InChI Key InChIKey=UAZFQVSPYRTWOA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 620875   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620875(US20230303540, Example Ex-6.10 | 1-(6-chloro-2-{[1...)
Affinity DataIC50: 0.200nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620875(US20230303540, Example Ex-6.10 | 1-(6-chloro-2-{[1...)
Affinity DataIC50: 1.79nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent