BDBM620858 (3S,4S) or (3R,4R) 4-(4-{2-[(5- chloro-1-cyclopropyl-1H- pyrazol-4-yl)amino]-6- methylquinazolin-7- yl}piperazin-1-yl)oxolan-3-ol::US20230303540, Example Ex-5.8

SMILES Cc1cc2cnc(Nc3cnn(C4CC4)c3Cl)nc2cc1N1CCN(CC1)C1COCC1O

InChI Key InChIKey=AEOJYZLICZISMI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 620858   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620858((3S,4S) or (3R,4R) 4-(4-{2-[(5- chloro-1-cycloprop...)
Affinity DataIC50: 0.170nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent