BDBM620672 6-chloro-N-[1-(2-fluoroethyl)-5- methyl-1H-pyrazol-4-yl]-7-[4- (3-methyloxetan-3-yl)piperazin- 1-yl]quinazolin-2-amine::US20230303540, Example Ex-1.5::US20230303540, Example Ex-4.12

SMILES Cc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)cnn1CCF

InChI Key InChIKey=HFURQTGDOKQMGX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 620672   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620672(6-chloro-N-[1-(2-fluoroethyl)-5- methyl-1H-pyrazol...)
Affinity DataIC50: 0.625nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620672(6-chloro-N-[1-(2-fluoroethyl)-5- methyl-1H-pyrazol...)
Affinity DataIC50: 0.625nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent