BDBM620474 US11767323, Example 24

SMILES COC1CCC(c2cc(=O)n(C)c3cnc4[nH]c(-c5cnn(C)c5)cc4c23)CC1

InChI Key InChIKey=KMDNLTCQMLOQBK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 620474   

LigandChemical structure of BindingDB Monomer ID 620474BDBM620474(US11767323, Example 24)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 620474BDBM620474(US11767323, Example 24)
Affinity DataIC50: 100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 620474BDBM620474(US11767323, Example 24)
Affinity DataIC50: 100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 620474BDBM620474(US11767323, Example 24)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2023
Entry Details
US Patent