BDBM619855 (3R,8aR)-7-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)-3-(4-fluoro-5-(2-(1-hydroxycyclopropyl)pyridin-4-yl)-1H-imidazol-2-yl)-2,3,8,8a-tetrahydroindolizin-5(1H)-one::US20230295157, Example 179

SMILES OC1(CC1)c1cc(ccn1)-c1[nH]c(nc1F)[C@H]1CC[C@@H]2CC(=CC(=O)N12)c1c(F)c(Cl)ccc1-n1cnnn1

InChI Key InChIKey=KYZQZFBGHSBBOB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 619855   

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619855(US20230295157, Example 179 | (3R,8aR)-7-(3-chloro-...)
Affinity DataIC50: 0.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
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TargetKallikrein-1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619855(US20230295157, Example 179 | (3R,8aR)-7-(3-chloro-...)
Affinity DataIC50: 1.40nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
Go to US Patent