BDBM619828 6-[2-[(3S,8a*R)-7-[3-chloro-2-fluoro-6-[4-(trifluoromethyl)triazol-1-yl]phenyl]-5-oxo-2,3,8,8a-tetrahydro-1H-indolizin-3-yl]-1H-imidazol-5-yl]-1H-quinolin-2-one::US20230295157, Example 152

SMILES Fc1c(Cl)ccc(c1C1=CC(=O)N2[C@H](CC[C@H]2c2ncc([nH]2)-c2ccc3[nH]c(=O)ccc3c2)C1)-n1cc(nn1)C(F)(F)F

InChI Key InChIKey=MFOPSUXCHYMMON-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 619828   

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619828(US20230295157, Example 152 | 6-[2-[(3S,8a*R)-7-[3-...)
Affinity DataIC50: 0.700nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
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TargetKallikrein-1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619828(US20230295157, Example 152 | 6-[2-[(3S,8a*R)-7-[3-...)
Affinity DataIC50: 1nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
Go to US Patent