BDBM619046 US20230295119, Compound 8G

SMILES CCC(=O)c1cnc(Nc2cc(ccn2)C(=O)NC)cc1Nc1cccc(-c2ncn(C)n2)c1OC

InChI Key InChIKey=WHPVYDYXVARYCM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 619046   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Gossamer Bio Services

US Patent
LigandPNGBDBM619046(US20230295119, Compound 8G)
Affinity DataIC50: 5nMAssay Description:Compounds described herein were tested for the ability to inhibit activity of human JAK1, JAK2 and JAK3, which was achieved using TR-FRET assays. Bri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Gossamer Bio Services

US Patent
LigandPNGBDBM619046(US20230295119, Compound 8G)
Affinity DataIC50: 500nMAssay Description:Compounds described herein were tested for the ability to inhibit activity of human JAK1, JAK2 and JAK3, which was achieved using TR-FRET assays. Bri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Gossamer Bio Services

US Patent
LigandPNGBDBM619046(US20230295119, Compound 8G)
Affinity DataIC50: 500nMAssay Description:Compounds described herein were tested for the ability to inhibit activity of human JAK1, JAK2 and JAK3, which was achieved using TR-FRET assays. Bri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Gossamer Bio Services

US Patent
LigandPNGBDBM619046(US20230295119, Compound 8G)
Affinity DataIC50: 500nMAssay Description:Compounds described herein were tested for the ability to inhibit activity of human JAK1, JAK2 and JAK3, which was achieved using TR-FRET assays. Bri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
Go to US Patent