BDBM6188 3-tert-butyl-1-[6-(3,5-dimethoxyphenyl)-2-{[3-(4-methylpiperazin-1-yl)propyl]amino}pyrido[2,3-d]pyrimidin-7-yl]urea::N-(tert-Butyl)-N -[6-(3,5-dimethoxyphenyl)-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]pyrido[2,3-d]pyrimidin-7-yl]urea::Pyrido[2,3-d]pyrimidine 103

SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)nc2nc1NC(=O)NC(C)(C)C

InChI Key InChIKey=VYWXBPWMVHMUQW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6188   

TargetPlatelet-derived growth factor receptor beta(Mouse)
University of Auckland

LigandPNGBDBM6188(N-(tert-Butyl)-N -[6-(3,5-dimethoxyphenyl)-2-[[3-(...)
Affinity DataIC50: 3.10E+4nMAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Auckland

LigandPNGBDBM6188(N-(tert-Butyl)-N -[6-(3,5-dimethoxyphenyl)-2-[[3-(...)
Affinity DataIC50: 19nMAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Auckland

LigandPNGBDBM6188(N-(tert-Butyl)-N -[6-(3,5-dimethoxyphenyl)-2-[[3-(...)
Affinity DataIC50: 2.60E+4nMAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Auckland

LigandPNGBDBM6188(N-(tert-Butyl)-N -[6-(3,5-dimethoxyphenyl)-2-[[3-(...)
Affinity DataIC50: 21nMAssay Description:Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed