BDBM618044 US20230286970, Compound 369::US20230286970, Compound 6

SMILES FC(F)c1nnc(o1)-c1ccc(Cn2cc(nn2)-c2cccc(NC(=O)N3CCOCC3)c2)nc1

InChI Key InChIKey=UTXOOXKUYRMOQL-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 618044   

TargetHistone deacetylase 6(Human)
Italfarmaco

US Patent
LigandPNGBDBM618044(US20230286970, Compound 6 | US20230286970, Compoun...)
Affinity DataIC50: 13nMAssay Description:For each test compound, 100× concentrated DMSO solutions at 8 doses were prepared and then diluted in assay buffer (25 mM Tris-HCl, pH 8, 130 mM NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Italfarmaco

US Patent
LigandPNGBDBM618044(US20230286970, Compound 6 | US20230286970, Compoun...)
Affinity DataIC50: 17nMAssay Description:For each test compound, 100× concentrated DMSO solutions at 8 doses were prepared and then diluted in assay buffer (25 mM Tris-HCl, pH 8, 130 mM NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetHistone deacetylase 2(Human)
Italfarmaco

US Patent
LigandPNGBDBM618044(US20230286970, Compound 6 | US20230286970, Compoun...)
Affinity DataIC50: 3.00E+4nMAssay Description:For each test compound, 100× concentrated DMSO solutions at 8 doses were prepared and then diluted in assay buffer (25 mM Tris-HCl, pH 8, 130 mM NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetHistone deacetylase 3(Human)
Italfarmaco

US Patent
LigandPNGBDBM618044(US20230286970, Compound 6 | US20230286970, Compoun...)
Affinity DataIC50: 3.00E+4nMAssay Description:For each test compound, 100× concentrated DMSO solutions at 8 doses were prepared and then diluted in assay buffer (25 mM Tris-HCl, pH 8, 130 mM NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetHistone deacetylase 4(Human)
Italfarmaco

US Patent
LigandPNGBDBM618044(US20230286970, Compound 6 | US20230286970, Compoun...)
Affinity DataIC50: 3.00E+4nMAssay Description:For each test compound, 100× concentrated DMSO solutions at 8 doses were prepared and then diluted in assay buffer (25 mM Tris-HCl, pH 8, 130 mM NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetHistone deacetylase 5(Human)
Italfarmaco

US Patent
LigandPNGBDBM618044(US20230286970, Compound 6 | US20230286970, Compoun...)
Affinity DataIC50: 3.00E+4nMAssay Description:For each test compound, 100× concentrated DMSO solutions at 8 doses were prepared and then diluted in assay buffer (25 mM Tris-HCl, pH 8, 130 mM NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetHistone deacetylase 11(Human)
Italfarmaco

US Patent
LigandPNGBDBM618044(US20230286970, Compound 6 | US20230286970, Compoun...)
Affinity DataIC50: 3.00E+4nMAssay Description:For each test compound, 100× concentrated DMSO solutions at 8 doses were prepared and then diluted in assay buffer (25 mM Tris-HCl, pH 8, 130 mM NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetHistone deacetylase 7(Human)
Italfarmaco

US Patent
LigandPNGBDBM618044(US20230286970, Compound 6 | US20230286970, Compoun...)
Affinity DataIC50: 3.00E+4nMAssay Description:For each test compound, 100× concentrated DMSO solutions at 8 doses were prepared and then diluted in assay buffer (25 mM Tris-HCl, pH 8, 130 mM NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
Italfarmaco

US Patent
LigandPNGBDBM618044(US20230286970, Compound 6 | US20230286970, Compoun...)
Affinity DataIC50: 3.00E+4nMAssay Description:For each test compound, 100× concentrated DMSO solutions at 8 doses were prepared and then diluted in assay buffer (25 mM Tris-HCl, pH 8, 130 mM NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPolyamine deacetylase HDAC10(Human)
Italfarmaco

US Patent
LigandPNGBDBM618044(US20230286970, Compound 6 | US20230286970, Compoun...)
Affinity DataIC50: 3.00E+4nMAssay Description:For each test compound, 100× concentrated DMSO solutions at 8 doses were prepared and then diluted in assay buffer (25 mM Tris-HCl, pH 8, 130 mM NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Italfarmaco

US Patent
LigandPNGBDBM618044(US20230286970, Compound 6 | US20230286970, Compoun...)
Affinity DataIC50: 2.00E+5nMAssay Description:For each test compound, 100× concentrated DMSO solutions at 8 doses were prepared and then diluted in assay buffer (25 mM Tris-HCl, pH 8, 130 mM NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Italfarmaco

US Patent
LigandPNGBDBM618044(US20230286970, Compound 6 | US20230286970, Compoun...)
Affinity DataIC50: 2.00E+5nMAssay Description:For each test compound, 100× concentrated DMSO solutions at 8 doses were prepared and then diluted in assay buffer (25 mM Tris-HCl, pH 8, 130 mM NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Italfarmaco

US Patent
LigandPNGBDBM618044(US20230286970, Compound 6 | US20230286970, Compoun...)
Affinity DataIC50: 1.00E+6nMAssay Description:For each test compound, 100× concentrated DMSO solutions at 8 doses were prepared and then diluted in assay buffer (25 mM Tris-HCl, pH 8, 130 mM NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent