BDBM617914 6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-3-(methoxymethyl)-N-(1-((R or S)-1-(6-methyl-5-((1R,5S)-2-oxo-3-azabicyclo[3.1.0]hexan-3-yl)pyrazin-2-yl)ethyl)-1H-pyrazol-4-yl)pyrazine-2-carboxamide::US20230286958, Example 126

SMILES COCc1nnc(nc1C(=O)Nc1cnn(c1)C(C)c1cnc(N2C[C@H]3C[C@H]3C2=O)c(C)n1)-c1c(F)c(Cl)ccc1C(F)F

InChI Key InChIKey=HKSQPHGJEPXYBV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 617914   

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617914(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-3-(...)
Affinity DataIC50: 0.5nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
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TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617914(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-3-(...)
Affinity DataIC50: 1.03E+3nMAssay Description:Assays were conducted at room temperature or at 37° C. Hydrolysis of the substrate resulted in release of amino trifluoromethylcoumarin (AFC), which ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent