BDBM616973 Synthesis of 6-(3-(3-((2-((R)-2,2-difluorocyclopropyl)phenyl)-sulfonyl)propanoyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)nicotinonitrile and 6-(3-(3-((2-((S)-2,2-difluorocyclopropyl)phenyl)sulfonyl)propanoyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)nicotinonitrile::US11752149, Example 35::US11752149, Example 36

SMILES FC1(F)C[C@@H]1c1ccccc1S(=O)(=O)CCC(=O)N1CC2CCC(C1)N2c1ccc(cn1)C#N

InChI Key

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 616973   

TargetMuscarinic acetylcholine receptor M1(Human)
Pipeline Therapeutics

US Patent
LigandPNGBDBM616973(US11752149, Example 35 | US11752149, Example 36 | ...)
Affinity DataIC50: 10nMAssay Description:Primary compound plates were prepared in 100% DMSO in opaque 96-well plates (VWR) and serially diluted in half log increments. Secondary compound pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M1(Human)
Pipeline Therapeutics

US Patent
LigandPNGBDBM616973(US11752149, Example 35 | US11752149, Example 36 | ...)
Affinity DataIC50: 550nMAssay Description:Primary compound plates were prepared in 100% DMSO in opaque 96-well plates (VWR) and serially diluted in half log increments. Secondary compound pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Pipeline Therapeutics

US Patent
LigandPNGBDBM616973(US11752149, Example 35 | US11752149, Example 36 | ...)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Pipeline Therapeutics

US Patent
LigandPNGBDBM616973(US11752149, Example 35 | US11752149, Example 36 | ...)
Affinity DataIC50: 550nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Pipeline Therapeutics

US Patent
LigandPNGBDBM616973(US11752149, Example 35 | US11752149, Example 36 | ...)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
Go to US Patent