BDBM6165 1,6-naphthyridine 34::3-tert-butyl-1-[3-(2,6-dichlorophenyl)-7-{[3-(4-methylpiperazin-1-yl)propyl]amino}-1,6-naphthyridin-2-yl]urea::N-(tert-Butyl)-N -[3-(2,6-dichlorophenyl)-7-[[3-(4-methyl-1-piperazinyl)propyl]amino]-1,6-naphthyridin-2-yl]urea

SMILES CN1CCN(CCCNc2cc3nc(NC(=O)NC(C)(C)C)c(cc3cn2)-c2c(Cl)cccc2Cl)CC1

InChI Key InChIKey=TWGNTRGLYZCJJT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6165   

TargetPlatelet-derived growth factor receptor beta(Mouse)
University of Auckland

LigandPNGBDBM6165(3-tert-butyl-1-[3-(2,6-dichlorophenyl)-7-{[3-(4-me...)
Affinity DataIC50: 620nMAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Auckland

LigandPNGBDBM6165(3-tert-butyl-1-[3-(2,6-dichlorophenyl)-7-{[3-(4-me...)
Affinity DataIC50: 26nMAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Auckland

LigandPNGBDBM6165(3-tert-butyl-1-[3-(2,6-dichlorophenyl)-7-{[3-(4-me...)
Affinity DataIC50: 19nMAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Auckland

LigandPNGBDBM6165(3-tert-butyl-1-[3-(2,6-dichlorophenyl)-7-{[3-(4-me...)
Affinity DataIC50: 14nMAssay Description:Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed