BDBM615214 3-[2-(4-fluorophenyl)-1H-indol-3-yl]-N-[(3R,4S)-4-hydroxy-2-oxo-pyrrolidin-3-yl]propanamide (134)::US20230271945, Compound 134

SMILES O[C@H]1CNC(=O)[C@@H]1NC(=O)CCc1c([nH]c2ccccc12)-c1ccc(F)cc1

InChI Key InChIKey=CNYZYDUBGMRAFP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 615214   

TargetApolipoprotein L1(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 615214BDBM615214(3-[2-(4-fluorophenyl)-1H-indol-3-yl]-N-[(3R,4S)-4-...)
Affinity DataIC50: 5.25E+4nMAssay Description:Apolipoprotein L1 (APOL1) proteins form potassium-permeable cation pores in the plasma membrane. APOL1 risk variants (G1 and G2) induce greater potas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent