BDBM614213 US11746110, Example 8

SMILES COCCn1cc(Nc2nccn3c(cnc23)C#Cc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1

InChI Key InChIKey=TWDJVIDAYJLYKW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 614213   

TargetTyrosine-protein kinase ABL1(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM614213(US11746110, Example 8)
Affinity DataIC50: 2.55nMAssay Description:Reagents and materials: ABL (ThermoFisher, Cat. No. PV3585), ABL T315I(Thermo Fisher, Cat. No. PR7429B), Ret (Carna, Cat. No. 08-159-10 ug), RET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2023
Entry Details
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TargetTyrosine-protein kinase ABL1 [T315I](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM614213(US11746110, Example 8)
Affinity DataIC50: 6.47nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2023
Entry Details
Go to US Patent