BDBM613504 1-[1-(cyanomethyl)-4-(4- phenylanilino)cyclohexyl]-3- (cyclopropanecarbonylamino) pyrazole-4-carboxamide::US11731943, Example 245

SMILES NC(=O)c1cn(nc1NC(=O)C1CC1)C1(CC#N)CCC(CC1)Nc1ccc(cc1)-c1ccccc1

InChI Key InChIKey=QCARNYLSFQGLBU-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 613504   

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM613504(US11731943, Example 245 | 1-[1-(cyanomethyl)-4-(4-...)
Affinity DataKi:  0.230nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM613504(US11731943, Example 245 | 1-[1-(cyanomethyl)-4-(4-...)
Affinity DataKi:  0.920nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent