BDBM613480 3-[(2- cyanocyclopropanecarbonyl) amino]-1-[4-(cyanomethyl)-1-[[4-(4- ethylphenyl)-3-hydroxy- phenyl]methyl]-3-fluoro-4- piperidyl]pyrazole-4- carboxamide::US11731943, Example 221::US11731943, Example 222

SMILES CCc1ccc(cc1)-c1ccc(CN2CCC(CC#N)(C(F)C2)n2cc(C(N)=O)c(NC(=O)C3CC3C#N)n2)cc1O

InChI Key InChIKey=JDRMNGOLXJPKRA-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 613480   

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM613480(US11731943, Example 221 | 3-[(2- cyanocyclopropane...)
Affinity DataKi:  0.180nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM613480(US11731943, Example 221 | 3-[(2- cyanocyclopropane...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM613480(US11731943, Example 221 | 3-[(2- cyanocyclopropane...)
Affinity DataKi:  0.430nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM613480(US11731943, Example 221 | 3-[(2- cyanocyclopropane...)
Affinity DataKi:  1.70nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent